rs1799782
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The aim of this study was to investigate the relationship between the presence of allelic variants Arg194Trp (rs:1799782) and Arg399Gln (rs: 25487) of XRCC1 gene and Thr241Met (rs: 861539) of XRCC3 gene and susceptibility to oral cancer.
|
22775506 |
2013 |
rs1799782
|
|
|
0.080 |
GeneticVariation |
BEFREE |
However, after stratification, significant association was found between the XRCC1 Arg194Trp polymorphism and oral cancer risk among Asians, showing an OR of 1.347 (95% confidence interval (CI): 1.000, 1.814) for allele comparison, 1.378 (95% CI: 1.070, 1.775) for TT homozygotes versus CC homozygotes, and 1.420 (95% CI: 1.041, 1.936) for comparison under the dominant model.
|
19713684 |
2009 |
rs1799782
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The best two-factor based G×G interaction of ora</span>l cancer included the XRCC1 rs1799782 and XRCC2 rs2040639 [OR=3.13, 95% CI=1.66-6.13].
|
25831063 |
2015 |
rs1799782
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Subgroup analysis by ethnicity suggested that there was an obvious association between XRCC1 Arg194Trp polymorphism and ora</span>l cancer</span> risk in Asians under three genetic models.
|
23681796 |
2013 |
rs1799782
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The meta-analysis results suggest that the XRCC1 Arg399Gln and Arg280His polymorphisms are probably not associated with the risk of HNC, but the XRCC1 Arg194Trp polymorphism was associated with increased risk of HNC in the subgroup analysis of studies adjusted for smoking and alcohol and with increased risk of oral cancer in the stratified analyses based on cancer site.
|
24497981 |
2014 |
rs1799782
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Subgroup analyses according to ethnicity, tumor site, publication year, genotyping method also detected no significant association in any subgroup, except that oral cancer was associated with Arg194Trp variant in recessive model.
|
24086310 |
2013 |
rs1799782
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Similarly, the pseudo-haplotype of rs2040639-rs861539-rs2075685 (XRCC2-XRCC3-XRCC4) and rs2040639-rs861539-rs2075685-rs1799782 (XRCCs 1-4) with specific genotype pattern (AG-CC-TG and CT-AG-CC-TG) among three and four combinational SNPs were significantly associated with oral cancer.
|
18410587 |
2008 |
rs1799782
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Among these 14 variants, 9 variants were reported to be significantly associated with the risk of oral cancer (CYP1A1-MspI, CYP2E1-RsaI/PstI, MTHFR-C677T, p73-G4C14-to-A4T14, XRCC1-Arg194Trp, CYP1A1-Ile462Val, GSTM1-±, and NAT2 slow vs rapid).
|
24102947 |
2014 |